Simple Spectrophotometric Determination of Esomeprazole Magnesium in Pharmaceutical Formulations

Authors

  • Purushotham Reddy M. Department of Chemistry, Government College for Men Kurnool(Dt), Andhra Pradesh, India Author
  • aveendra Reddy P Department of Chemistry, S. K. University, Anantapur- (Dt), Andhra Pradesh, India Author
  • N . Rami Reddy Department of Chemistry, S.B.S.Y.M. Degree College, Kurnool(Dt), Andhra Pradesh, India Author

DOI:

https://doi.org/10.5530/7w71e739

Keywords:

Spectrophotometry, Bromocresol green, Esomeprazole magnesium,, Pharmaceutical dosage form

Abstract

A simple, fast and reliable spectrophotometric method was developed for determination of esomeprazole magnesium in pharmaceutical formulations. The method is based on the reaction of esomeprazole magnesium with bromocresol green, the formed ion pair complex extracted into chloroform at pH 3.5. The chloroform extractable layer is measured at 420 nm against reagent blank. Beer's law obeyed in concentration of 50-250 μg/ml of esomeprazole magnesium. The method is validated statistically.

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Published

2011-09-30

Issue

Vol. 1 No. 3 (2011)

Section

Articles

How to Cite

Simple Spectrophotometric Determination of Esomeprazole Magnesium in Pharmaceutical Formulations. (2011). Asian Journal of Pharmaceutical and Health Sciences, 1(3), 135-136. https://doi.org/10.5530/7w71e739