The predictors of growth response to growth hormone therapy in growth hormone deficient Egyptian children

Authors

  • Nagwa Abdallah Ismail Department of Pediatrics, National Research Centre, Egypt Author
  • Nermeen Salah Eldin Metwaly Departments of Pediatrics and Clinical Pathology, Cairo University, Cairo, Egypt Author
  • Fatma Ahmed El-Moguy Faculty of Medicine, Cairo University, Cairo, Egypt Author
  • Mona Hassan Hafez Departments of Pediatrics and Clinical Pathology, Cairo University, Cairo, Egypt Author
  • Soha M. Abd El Dayem Department of Pediatrics, National Research Centre, Egypt Author
  • Tarek Mohamed Farid Department of Pediatrics, National Research Centre, Egypt Author

DOI:

https://doi.org/10.5530/dxgr9c95

Keywords:

bone age, growth hormone deficient, growth hormone therapy, predictors

Abstract

Short stature is one of the most common concerns presenting to pediatric endocrinologists and other physicians caring for children. Our aim is to identify the predictors of growth response to Growth hormone in GHD children. Factors (demographic, auxological) that may determine the response to GH therapy in 449 (GHD) patients followed for 4 years. Males and females with a mean age at the start of therapy of 11.9±3.4 years and 11.4±2.7 years for males and females respectively. Only 98 patients were followed for 4 years and the delta changes of them showed; height was significantly improved from 4.1 to 2.9 (p-value = 0.0001) and their GV were significantly decreased from 9 cm (5.2 SDS) to 5.4 cm (1.1 SDS) (p-value = 0.0001) of catch up growth during the first two years of GH therapy, height and 
weight deficit, GH peak levels and bone age delay were the main predictors.

Author Biographies

  • Nagwa Abdallah Ismail, Department of Pediatrics, National Research Centre, Egypt

     

       
  • Nermeen Salah Eldin Metwaly, Departments of Pediatrics and Clinical Pathology, Cairo University, Cairo, Egypt

     

     
  • Fatma Ahmed El-Moguy, Faculty of Medicine, Cairo University, Cairo, Egypt

     

     
  • Mona Hassan Hafez, Departments of Pediatrics and Clinical Pathology, Cairo University, Cairo, Egypt

     

     
  • Soha M. Abd El Dayem, Department of Pediatrics, National Research Centre, Egypt

     

     
  • Tarek Mohamed Farid, Department of Pediatrics, National Research Centre, Egypt

     

     

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Published

2015-12-30

Issue

Vol. 5 No. 4 (2015)

Section

Articles

How to Cite

The predictors of growth response to growth hormone therapy in growth hormone deficient Egyptian children. (2015). Asian Journal of Pharmaceutical and Health Sciences, 5(4), 1336-1342. https://doi.org/10.5530/dxgr9c95