Clear Cell Carcinoma of ovary, uterine corpus and cervix-Synchronous or metastatic ?

Abstract

Clear cell carcinoma is a rare type of ovarian epithelial malignancy accounting for less than 5% of all ovarian epithelial cancers. It is characterized by appearance of special type of cells with abundant clear cytoplasm and centrally placed nuclei arranged in solid or tubulo-cystic/glandular pattern with presence of hobnail cells frequently. Due to bad prognosis, it is considered as a high grade tumor. Ovarian clear cell carcinoma spreading to uterus and cervix is a very rare presentation. In such instances it becomes difficult to distinguish a metastatic lesion to uterus and cervix from ovarian primary from synchronous or simultaneous appearance of multiple cancers. We present such a case of ovarian clear cell carcinoma with concurrent involvement of uterus and cervix in a 60-year-old multiparus female. Simultaneously, we have tried to solve the conflict of metastatic and synchronous lesions in ovary and uterus.